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One of the metabolites of trazodone, and of nefazodone as well, is something called meta-chlorophenylpiperazine or mCPP, and abrupt increases in mCPP can be both dysphorogenic and anxiogenic, and even hallucinogenic

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Environmental Protection Agency (EPA) notes that change is on the horizon

Researchers often investigate these peptides in cell culture systems that analyze fibroblast activity, endothelial cell migration, and extracellular matrix organization