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Key gaps to address: dose-response in humans, safety/tolerability profiles across populations, interaction effects in stacks, and long-term cardiometabolic outcomes

Moreover, the region of DAT (M 1 - V 15 : MSKSKCSVGPMSSVV) responsible for mediating the interaction with D2R is identical between mice and rats, which the same amino acid sequence was used to synthesized TAT-DAT NT