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In five multiple-dose studies in healthy subjects (N=82) and in subjects with epilepsy (N=86), when administered under fasting and nonfasting conditions, divalproex sodium extended-release tablets given once daily produced an average bioavailability of 89% relative to an equal total daily dose of divalproex sodium delayed-release tablets given BID, TID, or QID

doi: 10.1016/j.bbamcr.2018.02.010 40 XuTGaoPHuangYWuMYiJZhouZet al

Patients present with mild to severe chronic hemolytic anemia and eventually develop hemochromatosis and its complications, which may be exacerbated by transfusion and coinheritance of other hematopoietic disorders

Cline, H