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The top five bioactive compounds, phytofluene, naringin, hesperidin, zeta-carotene, and cis -phytoene, bind to the binding site of IL1RAP, with binding energy values of 10.23 (Figure 5A), 10.21, 10.19, 9.74, and 9.71 kcal/mol, respectively

Published preclinical data in rodents suggests doses equivalent to 200mg+ in humans produce off-target effects on folate metabolism and S-adenosylmethionine (SAMe) pools

The consequences can be as severe as triggering autoimmune diseases or compromising your body's ability to fight infections

396,397 Interventions for Ulcerative colitis The progression of UC is a complex process that is attributed primarily to genetics and the environment and secondarily to a disturbance of the gut microbiota, 398,399 abnormal immunoregulation, 400 and psychological stress