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Thirdly, lactate and the acidic pH act as potent modulators of the immune response, suppressing the activity of cytotoxic T lymphocytes and natural killer (NK) cells while favoring the recruitment of immunosuppressive regulatory T cells (Tregs) and TAMs

D1-like DRs stimulate the activity of AC by activating Gs/olf, thus promoting the production of cAMP, which directly binds to NLRP3, triggering the ubiquitination of NLRP3 NACHT and LRR domains with K48 ubiquitin chains by the E3 ubiquitin ligase membrane associated ring-CH-type finger 7, targeting NLRP3 to autophagy-mediated degradation (85)

It represents a fundamentally different approach to treating autoimmune disease

c , Ligand-receptor interactions induced at 12 h after autoantibody injection in mice