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The interaction between MT and ACP may supply long-chain fatty acid precursors for remodeling mitochondrial phospholipids or provide octanoyl-ACP for alpha-lipoic acid biosynthesis for maintaining mitochondrial respiratory chain function [155]

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BSO alters the expression of genes involved in GSH biosynthesis, redox status, and protein homeostasis in kidneys To gain mechanistic insights, we quantified mRNA levels of several genes involved in mechanisms that compensate for low tGSH ( Gclc , Gclm , Gss , and Cth ), GSH redox status ( G6pdx , Me1 , Me2 , and Me3 ), and protein folding and degradation ( Pgd , Txn1 , Bag3 , and Erdj5 ), and other genes associated with one or more of these functions ( G6pdx , Mt1 , Mt2 , Erdj5 , and Txn1 ) in kidneys