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In 1926, after Minot and Murphys success with liver therapy for pernicious anemia, William Bosworth Castle (1897-1990), then an assistant resident at the Thorndike Memorial Laboratory of Boston City Hospital (which had recently come under the direction of Minot as successor to Francis Peabody), decided to pursue his belief that gastric achlorhydria (achylia gastrica) was etiologically linked to pernicious anemia (139)

PF and FF from women with endometriosis caused significantly greater chromosome and spindle misalignments in bovine and mouse MII oocytes than PF and FF from control women ( Sperm from healthy men was co-incubated with PF from patients with endometriosis vs