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Visceral adipocytes (the fat cells surrounding organs in the abdominal cavity) are highly sensitive to GH and IGF-1 signaling

Serum testosterone concentrations predict development of hyperglycaemia in population studies ( in vitro , androgen excess induces peripheral insulin resistance and pancreatic -cell insulin hypersecretion in both female human and mouse cell culture models, predisposing to onset of -cell failure and T2DM (Roland et al., 2010), while locally generated androgens in female adipose tissue may drive de novo lipogenesis and adipocyte hypertrophy (OReilly et al., 2017)