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Furthermore, in the livers of rats with diabetes, there was an accelerated rate of MT expression and cytoplasmic MT turnover, whereas in the kidneys, only the expression rate of MTs was increased, but not their cytoplasmic turnover [123, 130]

It is worth noting that EQUIP and CONQUER noted mood and memory disturbance, which may be troublesome in older adults, but commonest side effects were dry mouth, paraesthesia, constipation, and insomnia [111, 112]

10.1074/jbc.M105395200 J

Kraus et al., Nature Medicine show that NNMT inhibition can increase energy expenditure and improve metabolic health without altering diet or activity