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Myokines, for example, secreted by skeletal muscle cells during exercise such as -aminoisobutyric acid, can impair adipogenesis via activating AMPK signaling pathway and reducing levels of proinflammatory cytokines such as TNF- [81]

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Preclinical models have examined how this fragment influences fat cell mobilization and lipogenesis without measurable impact on insulin-like growth factor-1 (IGF-1) levels, distinguishing it mechanistically from intact growth hormone