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In a further aspect of the invention, one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein)

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Cellular Therapy and Stem Cells for Insomnia offer hope by targeting the foundational dysfunctions: Hypothalamic Neurons: Key regulators of the circadian rhythm (especially in the suprachiasmatic nucleus), these neurons may become desynchronized, impairing sleep initiation and maintenance