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The nasal mucosa is rich in blood vessels and the lymphatic system, which is conducive to the absorption and transportation of drugs [90, 91]

This means that in this case the respective 9 to 11 membered heterobicyclyl is incorporated into L 1 via two adjacent ring atoms and the ring atom of said 9 to 11 membered heterobicyclyl, which is adjacent to the carbon atom of the amide bond, is also a carbon atom

In this study, we also investigated the impact of modulating serine metabolism on IFN--driven inflammatory responses in keratinocytes and found that SHIN1 efficiently inhibited this pathogenic pathway, reducing the expression of CXCL9, CXCL10, CCL2, CCL5, IL-6, and HLA-DR