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The role of the IGF-I receptor in the growth and transformation of mammalian cells

Specifically, in HER2 + breast cancer cells, increased CD36 expression promotes FA uptake to compensate for the reduced FA synthesis caused by HER2 inhibition and enhances cancer cell resistance to lapatinib [225]

Therefore, icariin and icaritin promote the infiltration of immune cells, inhibit various immune checkpoints, reduce the levels of inflammatory cytokines and enhance anti-cancer immunity