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306 Exposure to arsenic can result in toxicity, primarily caused by the generation of reactive oxygen intermediates during its redox cycling and metabolic activation

CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial

Future directions include nanoparticle systems bearing dual targeting (e.g., neutrophil receptor + adipose microenvironment ligand) and ROSresponsive release of antiNET agents timed to metabolic stress windows (e.g., postovulation, insulin surge)