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H 2 O 2 mediated cell signalling and re-epithelialisation Many cytoskeletal proteins possess cysteines which are highly sensitive to oxidation 114 , and in a complementary fashion, production of H 2 O 2 occurs primarily in leading edge cells involved in re-epithelialisation 115

In addition, the prioritized reactions clustered in central carbon metabolism and amino acid pathways linked to cysteine-methionine and arginine-proline metabolism, we implemented in-depth analysis of flux distribution focused on those pathways