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The authors have also proposed an equilibrium-based model to characterize drug-surfactant interactions in pH-controlled systems, reflecting both interactions and interdependence among all drug-containing species: unionized drug in water, ionized drug in water, unionized drug in micelles, and ionized drug in micelles

And -SMA is a marker of smooth muscle cells and myofibroblasts, which are the important effector cells in the process of fiber formation

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This includes: Direct evidence: directly measured experimental support that blocking or preventing a KE prevents or impacts downstream KEs in the pathway in the expected fashion