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Harris, I

2018 Dec 1;47(6):195671

Science 312, 1389-1392CrossRefGoogle ScholarPubMed 130Beers, D.R., Henkel, J.S., Xiao, Q

First, the molecular trigger specificity of oxalate-induced ferroptosis in renal tubular cells is undefinedhow oxalate precisely initiates the synergistic dysregulation of iron uptake (TFR1), lipid metabolism (ACSL4), and antioxidant defense (GPX4/SLC7A11) remains elusive, with no clarity on upstream signaling molecules or post-translational modifications that link oxalate exposure to ferroptosis machinery