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The idea was further validated by inhibiting glutathione synthesis by BSO where Sp administration caused GSH to increase by ~1.5 fold with concomitant reduction in GSSG (Fig

This gap in research is another reason to use moderate, evidence-based doses rather than assuming "more is better." If you're taking medications for cancer treatment, diabetes, or cardiovascular conditions, consult your healthcare provider before adding glutathione supplements, as potential interactions could affect medication effectiveness or create unexpected complications

& Miszalski, Z

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