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H.FrederiksenJ

However, it will not crush your cravings, bypass a poor diet, or trigger overnight drops on the scale

Proc Natl Acad Sci USA (2016) 113(48):E777887

This is because there is a mutation or abnormality in the relevant gene: COL1A2 for cvEDS, and COL1A1 and COL3A1 for vEDS (no gene has been identified yet for hEDS)