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The applicant asserted that for these reasons NexoBrid TM is a treatment option for a patient population unresponsive to, or ineligible for, currently available enzymatic and surgical eschar removal treatments

Specific measures Antivirals (eg, topical or oral aciclovir, or valaciclovir) commenced within 48 hours of symptom onset may reduce the duration of symptoms and risk of recurrence

Markedly increased studies demonstrate multiple cell death pathways arise in CD patients and experimental models [3]

Factors such as trauma, nutritional deficiencies, irritable bowel disorders, leaky gut, microbiome dysbiosis, and immune dysregulation can all contribute to the generation of ROS, leading to tissue damage and ulcer formation