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The studies, which include maternal immune activation (MIA) in mice (poly (I:C)) and prenatal VPA exposure in rats, demonstrate that antipurinergic therapy (APT) with suramin (20 mg/kg) results in improvements of impaired social behaviors

The Brain Is One of the First Affected Systems The brain is especially vulnerable to oxidative stress because it: uses a large amount of oxygen has high metabolic demand relies heavily on mitochondrial function When oxidative stress increases, it can disrupt: neurotransmitter (hormone) balance blood flow energy production This contributes directly to: cognitive dysfunction slowed processing sensory sensitivity sleep disturbances Glutathione: Your Bodys Master Antioxidant One of the most important defenses against oxidative stress is: Glutathione Glutathione helps: neutralize free radicals detoxify harmful substances support immune regulation protect brain and mitochondrial function Key insights: Levels naturally decline with age (often starting in your 30s) Illness, stress, and inflammation accelerate depletion COVID-19 may significantly reduce glutathione availability This has led researchers to explore glutathione depletion as a key factor in Long COVID symptom persistence

Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H, et al

Carcinogenesis Lifetime carcinogenicity studies were conducted with ziprasidone in Long Evans rats and CD-1 mice