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[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Chen K., Jin S., Chen H., Cao Y., Dong X., Li H., Zhou Z., Liu C

However, following ingestion of a large overdose (150 mg/kg or greater) the glucuronide and sulfate conjugation pathways are saturated resulting in a larger fraction of the drug being metabolized via the P-450 pathway