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The SCN, located above the optic nerve crossing, plays a pivotal role in regulating the timing of sleep and wakefulness [174]

Bibcode:2012Natur.488..471K

The phosphorylation of Beclin-1 by AMPK generates a complex with SLC7A11, thereby inhibiting its function as a Cys transporter and stimulating lipid peroxidation and iron metabolism (157)