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Weekly dosage recommendations for glutathione injections are highly individualized

& Kong, J

The thiol residues on the topoisomerase ll-DNA complex were exposed and were alkylated by naphthoquinones, thereby providing a biomimetic model of topoisomerase II poisoning by quinones

Under this condition i.e., the pharmacological agent could not covalently bind the transporter (see Materials and methods), the experimental data resembled those obtained with the C-less protein (not shown)