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Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting

In summary, the findings so far discussed point each other to the role of androgen/AR pathway impairment in skeletal muscle wasting, sarcopenia progression, obesity, insulin-resistance, inflammation and immuno-senescence

The mechanisms underlying MMA-induced brain damage are multifactorial, encompassing mitochondrial dysfunction (energy failure/oxidative stress), neuroinflammatory responses, excitotoxicity secondary to neurotransmitter imbalance and ultimately, cell death pathways