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To visualize small-molecule metabolites localized within TLS, we used matrix-assisted laser desorption/ionization time of flight imaging mass spectrometry and found significant accumulation of glutathione (reduced form: glutathione [GSH], oxidized form: glutathione disulfide [GSSG]) within TLS (Figure 1C)

Recently, it has been demonstrated that a combination of azathioprine with BSO is useful for localized treatment of human hepatocellular carcinoma [62]

A detailed discussion of redox control of gene expression is beyond the scope of this review, and therefore, only a brief summary will be outlined here

Persistent mitochondrial dysfunction linked to prolonged organ dysfunction in pediatric sepsis