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Systemic chemotherapy interferes in homocysteine metabolism in breast cancer patients

A path branches from serine to glycine in which the -CH 2 OH part of the serine side chain is split off and the C 1 unit is accepted by the already mentioned tetrahydrofolate (THF)

At present, the primary approach to inhibit DNA synthesis in actively proliferating tumor cells in patients with OC is achieved by using platinum- and paclitaxel-dependent chemotherapy (106)