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Its a common symptom that leads to 7 million ambulatory visits in the US

Recent research suggests that there is a class of neurons in contact with CSF on the ependyma called CSF-contacting neurons (CSF-cNs), and the location of CSF-cNs and ciliary morphology suggests that they sense physical and chemical signals in the CSF (Orts-DelImmagine and Wyart, 2017)