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Apurinic/Apyrimidinic (AP) sites in the brain, spinal cord, and brainstem of ALS patients are vulnerable to DNA lesions induced by free radicals and intermediates (Kim et al., 2020)

J Biomed Res 28:169177

Participants treated with safinamide (50 mg/day or 100 mg/day) experienced significant improvements in ON time compared to placebo, with mean increases of 1.3 hours in the safinamide groups versus 0.7 hours in the placebo group (50 mg/day, p = 0.022