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Description

Cisplatin exerts its cytotoxic effects through a complex interplay of molecular mechanisms, primarily by coordinating DNA to form platinumDNA adducts, resulting in DNA damage, mitochondrial dysfunction, reactive oxygen species (ROS) generation, modulation of cell death pathways and subsequent apoptosis [7]

L.JonathanW

IgM antibodies appear 2-3 weeks after infection, while IgG requires 6-8 weeks to be detected

Among immune cells, FcRn is expressed by monocytes, macrophages, dendritic cells, and neutrophils, and is present at low levels in B lymphocytes but not detectable on T lymphocytes and NK cells