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Comparative studies show that while HICs absorb higher per-patient costs through insurance systems and assistive infrastructure, LMICs face a disproportionately higher household-level burden, where out-of-pocket expenses can consume over 50% of monthly income (Ola et al., 2022) (Figures 4, 5)

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Reduced heart exposure of diclofenac by its polymeric micellar formulation normalizes CYP-mediated metabolism of arachidonic acid imbalance in an adjuvant arthritis rat model: implications in reduced cardiovascular side effects of diclofenac by nanodrug delivery

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