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261 On the other hand, SIRT4 suppresses tumor growth by inhibiting glutamine metabolism, 262,263 and upon downregulation, it inhibits apoptosis and desensitizes cancer cells to chemotherapy

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With chloroquine and hydroxychloroquine treatment, cardiomyopathy, neurological, and gastrointestinal side effects have been observed, and because COVID-19 patients are more sensitive due to co-morbidities, there are worries about safety (Table 2) ( Statin treatment in patients with ARDS and sepsis has yielded unsatisfactory results, leading to skepticism about using them as COVID-19 therapy adjuncts