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As the activation of CD8+ T cells by the anti-PD1 treatment results in the upregulation of CD38, these reinvigorated cells become an immediate target for Daratumumab-mediated lysis, thus abrogating the effectiveness of anti-PD1 treatment

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Genetic and pharmacologic NNMT suppression reduces adiposity and improves metabolic readouts in preclinical models, with supportive cellular data showing increases in NAD and SAM and suppression of lipogenesis