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Furthermore, the NNMT SNP rs694539 increases risk of acute lymphoblastic leukemia ( NNMT is expressed mainly in the liver and adipose tissue, and a small amount of NNMT can be detected in the kidney, lung, skeletal muscle, and the heart ( NNMT expression is altered in metabolic diseases such as obesity and cirrhosis (27), colorectal cancer (28), bladder cancer (29), ovarian cancer (30), cutaneous malignant melanoma (CMM) (31), gastric cancer (32), pancreatic cancer (33, 34), and glioblastoma (GBM) (35)

[PubMed abstract] Watanabe F, Yabuta Y, Bito T, Teng F

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Cystatin C: A More Accurate Option Cystatin C is a blood test that can detect kidney function changes earlier than creatinine, which is especially helpful if youre on high-dose B12 therapy