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Its bioactivation leads to excessive generation of ROS, including superoxide (O), hydrogen peroxide (HO), singlet oxygen, and hydroxyl radicals (OH), disrupting redox homeostasis in ovarian tissue (Trujillo et al

It can also counteract dryness and stinging

However, other researchers have argued that controversial issues exist because GPNA also inhibits other glutamine transporters, such as SLC38A1, and V-9302 is effective even in SLC1A5 knockout models 206,207