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GSK-3, glycogen synthase kinase 3 beta

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As previous international studies have noted, the true prevalence rate of restless legs syndrome may actually be underestimated due to a variety of factors, including the belief that restless legs are a minor ailment that doesn't require medical attention, the fear that affected individuals will be shunned in some cultures, and the absence of symptoms when testing a patient while they are awake (Yeh et al., 2016)

Andrew Huberman , said on a recent episode of the Flagrant podcast