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In the highest dose arms, approximately 6070% of participants experienced at least one GI adverse event at some point during titration

Medical supervision ensures appropriate dosing protocols, monitoring for sleep quality improvements, assessment of individual response patterns, and integration with comprehensive sleep hygiene strategies including consistent sleep schedules, optimized sleep environment, light exposure management, stress reduction practices, and lifestyle factors that amplify DSIPs sleep-supporting benefits for optimal restorative sleep and recovery

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