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doi: 10.1007/s12603-011-0348-2

IBD is an umbrella term made of Crohn's disease and ulcerative colitis which are disorders that cause chronic inflammation in the GI tract

In UC, the inflammation is restricted to the rectum and the colon and never affects the small intestine

The citric acid cycle involves three NAD+-dependent dehydrogenase reactions: isocitrate dehydrogenase, -ketoglutarate dehydrogenase, and malate dehydrogenase, each generating NADH while releasing carbon dioxide and regenerating oxaloacetate for continued cycle operation