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In severe acute pancreatitis (SAP), inflammatory factors promote the expression of matrix metalloproteinases (MMPs) and heparinases, which degrade syndecan-1 (SDC-1) and HS, while oxidative stress disrupts HA-CD44 binding, leading to increased capillary leakage and neutrophil adhesion

Daniel Gordin was supported by Liv och Hlsa Society, Medical Society of Finland (Finska Lkaresllskapet), Sigrid Juselius Foundation, Helsinki University Hospital, University of Helsinki, Minerva Foundation Institute for Medical Research Clinician Scientist, and Academy of Finland (UAK1021MRI)

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The genuine human Phase II trials used full-length thymosin beta-4 as a topical eye drop for dry eye, and even those had mixed results on their primary endpoints