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Increased NNMT expression has also been reported in muscle-wasting conditions such as Duchenne Muscular Dystrophy (DMD)

For patients with unexplained mental and motor developmental delay, seizures, recurrent acute encephalopathy, and systemic multisystem manifestations, it is important to conduct early diagnostic investigations such as cranial MRI, EEG, plasma amino acid metabolism, urine organic acid metabolism analysis, CSF metabolism, and genetic testing to clarify the diagnosis

Further clinical trials should be conducted to determine the beneficial effects of CoQ10 supplementation on migraine attacks