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JAMA Network Open , 6(11), e2342210

Treatment of Leber's optic atrophy

In CUMS mouse models, Kai-Xin-San reduced LPS and pro-inflammatory cytokine levels while increasing tight junction protein expression in the gut and BBB, ameliorating depression-like behaviors through regulation of the gut microbiotainflammationstress system (Cao et al., 2020)

This interaction causes overexpression of adhesive molecules in endothelial cells which may be an initiating factor for the development of inflammation in the vascular wall