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Age predisposes individuals to have increased oxidative stress levels leading to the production of inflammatory cytokines, which is only exacerbated by COVID-19 infection

Studies have shown that ORAOV1 increases the intracellular proline concentration and subsequently reduces ROS production by binding to pyrrolin-5-carboxylate reductase (PYCR) in esophageal squamous cell cancer (ESCC), thereby increasing tumorigenicity and tumor growth [174]

As shown in Scheme 1A, GOx-CuCaP (GC) NPs were firstly prepared according to previous description with mild modification

Cross-linked agarose is commercially available (Sepharose) and it can be used with many solvents, over pH 3-14 and at high temperatures up to 70C [11]