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The vagus nerve is especially important, providing a direct neural highway between gut and brainstem: vagal afferent fibers transmit sensory signals from intestinal receptors, while efferent fibers carry brain commands to influence gut activity [21]

Oral peptide supplements provide a convenient non-invasive option, though they may face challenges with bioavailability and accurate dosage determination

During transit through the GIT, these bioactive compounds are exposed to multiple degradation conditions, including mastication, swallowing, gastric acidity, bile salts, enzymatic hydrolysis, and metabolic transformations

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