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4710-C PNPLA3 GENOTYPE IS ASSOCIATED WITH RISK OF HCC BUT NOT DECOMPENSATION IN PATIENTS WITH COMPENSATED CIRRHOSIS Esteban Urias 1 , Nicholas Tedesco 1 , Karn Wijarnpreecha 2 and Vincent Chen 3 , (1)University of Michigan, (2)University of Arizona College of Medicine Phoenix, Phoenix, AZ, (3)University of Michigan Medical Center Background: The PNPLA3 -rs738409-G, TM6SF2 -rs58542926-T, and HSD17B13 -rs6834314-A polymorphisms have been associated with cirrhosis, hepatic decompensation, and hepatocellular carcinoma (HCC)

EVs also decreased the expression of inflammatory genes in activated KCs in vitro : iNOS by 72.6%, TNF- by 54.9%, IL-6 by 35.6%, and IL-1 by 59.5%

As long as metabolic pathways are under systemic control and well-concerted together, adaptive mechanisms become triggered increasing systemic protection, activating antioxidant defense and repair machinery

doi: 10.1039/D1FO00986A 106 CassidyAMinihaneAM