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Real-world outcomes research from 2024 analyzing patients across multiple healthcare systems found that mepolizumab for asthma exacerbations reduced attacks by 60-67% in routine carehigher than the 47-53% seen in trialslikely because real-world patients have fewer restrictions on concomitant therapies. Regional Variations Reveal Consistent Efficacy: United States: Veterans Affairs healthcare data shows 71% of patients achieved asthma control with Nucala severe asthma treatment United Kingdom: National Health Service outcomes demonstrate 68% reduction in oral steroid use over 12 months India: PRISM study participants experienced 76% fewer exacerbations with excellent tolerability European Union: Multi-country registry data confirms 64% of patients maintain benefit beyond 3 years Long-term safety data spanning up to 10 years published in NIH journals reveals that mepolizumab side effects remain mild, with serious adverse events occurring in only 7% of patientsfar lower than long-term oral steroid complications

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