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A recent meta-analysis of 39 observational studies showed that serum Cu-to-Zn ratios were significantly higher in patients with lung cancer than in healthy controls and patients with benign lung disease (Zhang et al., 2022)

Since 1998, Scott and colleagues have regarded ME/CFS as a stress-related disorder and proposed that HPA-axis hypofunction may reflect a state of stress-related hypocortisolism or reduced HPA-axis drive (Scott et al., 1998)

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