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Description

These limitations have contributed to the lack of conclusive clinical efficacy observed to date (Kurkinen, 2023)

The metabolic shift from glucose utilization to ketone body consumption in malignant cells following KD implementation has been associated with enhanced AMPK stimulation [118,119,120,121,122]

When combined with prospective economic evaluations, these tools can support focused indications in which biological plausibility, clinical benefit and cost-effectiveness are aligned [116]