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Subgroup analyses by pathological stage of diagnosis, tumor grades, and surrogate subtypes were also performed with unconditional logistic regression models, in which breast cancer in each subgroup was the dependent variable and each carnitine compound (per 1-SD increase) was the independent variable

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The activation of mTOR leads to phosphorylation and activation of S6 kinases (S6Ks) and hyperphosphorylation of 4E-binding proteins (4E-BPs), resulting in the acceleration of protein synthesis