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In addition to its direct antitumor effects, daratumumab exerts an indirect immunomodulatory role by eliminating CD38 + immunosuppressive cell types (Treg, Breg and myeloid-derived suppressor cells) in the tumor microenvironment (TME), thereby promoting T-cell proliferation and effector functions [44]

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For most consumer-facing research-vial contexts, the simpler answer is: keep lyophilized powder frozen or refrigerated before mixing, keep reconstituted solution refrigerated after mixing, and avoid freeze-thaw cycles

The liquid state allows scientists to evaluate concentration accuracy and consistency within research protocols