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In B-cell lymphoma, DNA hypermethylation in the promoter region of Spry2 (a negative regulator of ERK signaling) results in its transcriptional silencing, thereby relieving inhibition of the MAPK-ERK pathway and enhancing cell proliferation and survival (Frank et al., 2009[32])

10.1016/j.brainres.2010.11.094 43 MenonM

2017;27(21):R1147-r1151

Pharmacological reduction of oxidative stress by administering Trolox, a water-soluble antioxidant and vitamin E analog, also partially rescued DNA damage and cellular toxicity in Drosophila expressing C9orf72 DPRs (Lopez-Gonzalez et al., 2016)